TERT Polymorphism rs2853669 Influences on Lung Cancer Risk in the Korean Population
Journal of Korean Medical Science
; : 1423-1428, 2015.
Article
ي En
| WPRIM
| ID: wpr-183079
المكتبة المسؤولة:
WPRO
ABSTRACT
Short telomeres are known as one of the risk factors for human cancers. The present study was conducted to evaluate the association between 6 polymorphisms, which were related with short telomere length in the Korean population, and lung cancer risk using 1,100 cases and 1,096 controls. Among the 6 polymorphisms, TERT rs2853669 was significantly associated with increased lung cancer risk under a recessive model (odds ratio [OR]=1.38, 95% confidence interval [CI]=1.05-1.81, P=0.02). The effect of rs2853669 on lung cancer risk was significant in younger individuals (OR=1.73, 95% CI=1.18-2.54, P=0.005) and adenocarcinoma (OR=1.50, 95% CI=1.07-2.07, P=0.02). Our results suggest that a common functional promoter polymorphism, TERT rs2853669, may influence both telomere length and lung cancer risk in the Korean population.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Adenocarcinoma
/
Case-Control Studies
/
Promoter Regions, Genetic
/
Telomere
/
Telomerase
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Genetic Association Studies
/
Republic of Korea
/
Telomere Homeostasis
نوع الدراسة:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
المحددات:
Female
/
Humans
/
Male
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
Journal of Korean Medical Science
السنة:
2015
نوع:
Article