Molecular Mechanisms of Appetite Regulation
Diabetes & Metabolism Journal
; : 391-398, 2012.
Article
ي En
| WPRIM
| ID: wpr-184817
المكتبة المسؤولة:
WPRO
ABSTRACT
The prevalence of obesity has been rapidly increasing worldwide over the last several decades and has become a major health problem in developed countries. The brain, especially the hypothalamus, plays a key role in the control of food intake by sensing metabolic signals from peripheral organs and modulating feeding behaviors. To accomplish these important roles, the hypothalamus communicates with other brain areas such as the brainstem and reward-related limbic pathways. The adipocyte-derived hormone leptin and pancreatic beta-cell-derived insulin inform adiposity to the hypothalamus. Gut hormones such as cholecystokinin, peptide YY, pancreatic polypeptide, glucagon-like peptide 1, and oxyntomodulin transfer satiety signals to the brain and ghrelin relays hunger signals. The endocannabinoid system and nutrients are also involved in the physiological regulation of food intake. In this article, we briefly review physiological mechanisms of appetite regulation.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Appetite
/
Appetite Regulation
/
Brain
/
Brain Stem
/
Cholecystokinin
/
Pancreatic Polypeptide
/
Developed Countries
/
Prevalence
/
Hunger
/
Peptide YY
نوع الدراسة:
Prevalence_studies
اللغة:
En
مجلة:
Diabetes & Metabolism Journal
السنة:
2012
نوع:
Article