18F-FDG PET/CT in the Clinical Assessment of Patients with Multiple Myeloma: A Pilot Study / 대한내과학회지

ABSTRACT

BACKGROUND/AIMS: This study investigated the clinical utility of positron emission tomography/computed tomography (PET/CT) for evaluating bone lesions in patients with multiple myeloma before therapy. METHODS: Whole-spine and pelvic magnetic resonance imaging (MRI) and whole-body PET/CT were conducted in patients newly diagnosed with multiple myeloma before therapy. We compared the PET/CT and MRI results for the entire spine and pelvis, and the discordance rates were cross-analyzed with the clinical factors. RESULTS: Ten patients were enrolled (median age 57.5 years). The majority were at an advanced stage, and IgG type multiple myeloma occurred in seven patients. All patients underwent PET/CT and 36 sites were checked on MRI. Approximately 69% of the patients had diffuse patterns, 8.3% had focal lesions, 5.6% had mixed lesions, and 16.7% had a normal pattern on MRI. The concordance rate of PET/CT compared with MRI was 83.3% (30 sites). The false-positive rate was 13.9% and the false-negative rate was 2.8%. No factor predicted the discordance between the PET/CT and MRI results. CONCLUSIONS: A well-designed, large-scale study is warranted to confirm the accuracy of PET/CT for detecting bone lesions in these patients.