Assessment of leukotriene E4 in exhaled breath condensate as a marker of inflammation and therapeutic effect in allergic rhinitis children
Allergy, Asthma & Respiratory Disease
; : 47-51, 2017.
Article
ي Ko
| WPRIM
| ID: wpr-189593
المكتبة المسؤولة:
WPRO
ABSTRACT
PURPOSE:
Recent studies have shown that the cysteinyl leukotriene (cysLT) of exhaled breath condensate (EBC) could be predictive of inflammatory status and effectiveness of treatment in allergic disease. The aim of this study was to evaluate the inflammation and therapeutic effectiveness of cysLT in EBC in pediatric patients with allergic rhinitis (AR).METHODS:
We enrolled 34 healthy children (median age, 4 years 10 months) and 67 AR children (median age, 5 years 1 month). All of the AR patients received intranasal steroid (fluticasone furoate) once daily for 2 weeks. After 2 week of fluticasone furoate treatment, they were classified into 2 groups the fluticasone furoate (F) and montelukast (M) groups. We treated each group for another 8 weeks. To evaluate the therapeutic effectiveness, we used symptom score (SS) and EBC leukotriene E4 (LTE4). EBC samples were collected with RTube. Each parameter was checked at 0, 2, and 10 weeks of therapy.RESULTS:
Most of the AR patients showed clinical improvement with 2- and 10-week fluticasone therapy (F group 0-week SS, 5.6; 2-week SS, 3.6; 10-week SS, 2.1; P<0.01; M group 0-week SS, 4.8; 2-week SS, 3.2; 10-week SS, 1.9 P<0.01). LTE4 levels were higher in AR patients than in control subjects (0 week 87 pg/mL vs. 18 pg/mL) and were reduced after 2 weeks of fluticasone treatment (F group 90→51.6 pg/mL, P<0.01; M group 84→46.1 pg/mL, P<0.01). After 10 weeks of treatment, there was no significant difference in the LTE4 level between the F and M groups.CONCLUSION:
LTE4 in EBC may be useful for evaluating inflammation and therapeutic effectiveness in patients with allergic rhinitis.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Leukotriene E4
/
Rhinitis, Allergic
/
Fluticasone
/
Inflammation
نوع الدراسة:
Prognostic_studies
المحددات:
Child
/
Humans
اللغة:
Ko
مجلة:
Allergy, Asthma & Respiratory Disease
السنة:
2017
نوع:
Article