Differential Expressions of Fas and Fas Ligand in Human Placenta
Journal of Korean Medical Science
; : 213-216, 2002.
Article
ي En
| WPRIM
| ID: wpr-197889
المكتبة المسؤولة:
WPRO
ABSTRACT
To investigate the expressions of Fas and Fas ligand (FasL) in human placenta, we studied the expressions of Fas and FasL in placenta with RT-PCR, immunoblotting and immunostaining. We observed amplified products of Fas and FasL transcripts, the band of Fas (52 kDa) and multiple bands of FasL (42-52 kDa) in pla-centa. Fas and FasL localized mainly on fetal vessels and on syncytiotrophoblasts respectively. The differential distribution of Fas and FasL in human placenta may reflect intrinsic expressions of them by trophoblasts during differentiation. The increased expression of Fas in trophoblasts may promote apoptosis of placenta in pathologic condition such as preeclampsia.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Placenta
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Trophoblasts
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Glycosylation
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Membrane Glycoproteins
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Immunoblotting
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Gene Expression
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Fas Receptor
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Reverse Transcriptase Polymerase Chain Reaction
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Gene Expression Profiling
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Fas Ligand Protein
المحددات:
Humans
اللغة:
En
مجلة:
Journal of Korean Medical Science
السنة:
2002
نوع:
Article