High-Dose Chemotherapy of Cyclophosphamide, Thiotepa and Carboplatin (CTCb) followed by Autologous Stem-Cell Transplantation as a Consolidation for Breast Cancer Patients with 10 or more Positive Lymph Nodes: a 5-Year follow-Up Results / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 137-142, 2005.
Article
ي En
| WPRIM
| ID: wpr-201934
المكتبة المسؤولة:
WPRO
ABSTRACT
PURPOSE:
The benefit of consolidation high-dose chemotherapy (HDC) for high-risk primary breast cancer is controversial. We evaluated the efficacy and safety of consolidation HDC with cyclophosphamide, thiotepa and carboplatin (CTCb) followed by autologous stem-cell transplantation (ASCT) in resected breast cancer patients with 10 or more positive lymph nodes. MATERIALS ANDMETHODS:
Between December 1994 and April 2000, 22 patients were enrolled. All patients received 2 to 6 cycles of adjuvant chemotherapy after surgery for breast cancer. The HDC regimen consisted of cyclophosphamide 1, 500 mg/m2/day, thiotepa 125 mg/m2/day and carboplatin 200 mg/m2/day intravenous for 4 consecutive days.RESULTS:
With a median follow-up of 58 months, 11 patients recurred and died. The median disease-free survival (DFS) and median overall survival (OS) were 49 and 69 months, respectively. The 5-year DFS and OS rates were 50% and 58%, respectively. The 12 patients with 10 to 18 involved nodes had better 5-year DFS (67%) and OS (75%) than 10 patients with more than 18 involved nodes (30% and 38%, respectively). The most common grade 3 or 4 nonhematologic toxicity was diarrhea, which occurred in 5 patients (23%). No treatment-related death was observed.CONCLUSION:
Consolidation HDC with CTCb followed by ASCT for resected breast cancer with more than 10 positive nodes had an acceptable toxicity but does not show promising survival.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Breast
/
Breast Neoplasms
/
Follow-Up Studies
/
Carboplatin
/
Chemotherapy, Adjuvant
/
Thiotepa
/
Disease-Free Survival
/
Cyclophosphamide
/
Peripheral Blood Stem Cell Transplantation
/
Diarrhea
نوع الدراسة:
Observational_studies
/
Prognostic_studies
المحددات:
Humans
اللغة:
En
مجلة:
Cancer Research and Treatment
السنة:
2005
نوع:
Article