Polymorphisms in the STAT-6 Gene and SLE / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
; : 26-29, 2005.
Article
ي Ko
| WPRIM
| ID: wpr-203091
المكتبة المسؤولة:
WPRO
ABSTRACT
OBJECTIVES:
To investigate whether the new polymorphism at position 2964 (G/A) in the 3' untranslated region of the STAT-6 gene is associated with susceptibility to systemic lupus erythematosus (SLE) and its clinical features.METHODS:
A polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the STAT-6 in 90 SLE patients and 148 healthy controls. Clinical and serological manifestations were analyzed in each patient and correlated with the genotypes. RESUTLS The genotype distribution of the STAT-6 differed significantly between SLE patients and control subjects (AA, AG, GG genotypes 7, 74, 9 vs. 1, 119, 28 controls respectively, p= 0.003). The frequency of AA genotype (7.8%) is significantly increased in SLE patients compared with controls (0.7%)(OR=12.398, 95% CI 1.50~102.5, Fisher's exact test, p=0.005). Clinically in the lupus patients according to the STAT-6 genotypes, there was no significant difference in age at onset, anti-ds-DNA titer, C3, C4 level, SLEDAI, SLICC/ACR Damage Index, or autoantibodies such as RF, anti-Ro, La, RNP, Sm antibodies, except for renal involvement. The frequency of lupus nephritis was significantly higher in the AA genotype in comparison with GG genotype (Fisher's exact test, p=0.019).CONCLUSION:
Our data show that the STAT-6 AA genotype may contribute to susceptibility to SLE and may be associated with development of lupus nephritis.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Polymorphism, Genetic
/
Autoantibodies
/
Lupus Nephritis
/
Polymerase Chain Reaction
/
3' Untranslated Regions
/
Genotype
/
Lupus Erythematosus, Systemic
/
Antibodies
المحددات:
Humans
اللغة:
Ko
مجلة:
The Journal of the Korean Rheumatism Association
السنة:
2005
نوع:
Article