Reproductive performance of genetically engineered mice housed in different housing systems / 한국실험동물학회지
Laboratory Animal Research
; : 68-75, 2017.
Article
ي En
| WPRIM
| ID: wpr-204560
المكتبة المسؤولة:
WPRO
ABSTRACT
The genetically engineered mice require special husbandry care and are mainly housed in Individually Ventilated Cage (IVC) systems and Static Micro Isolator Cages (SMIC) to minimize the risk for spreading undesirable microorganisms. However, the static micro isolation cage housing like SMIC are being replaced with IVC systems in many facilities due to a number of benefits like a higher density housing in limited space, better protection from biohazards and allergens and decreased work load due to decreased frequency of cage changing required in this system. The purpose of this study was to examine the reproductive performance of genetically engineered mice housed in individually ventilated cages (IVC) and Static Micro Isolator Cages (SMIC). When the B6C3-Tg (APPswe, PSEN1dE9) 85Dbo/Mmjax transgenic mice were housed in these two housing systems, the number of litters per dam, number of pups born per dam and number of pups weaned per dam were found to be slightly higher in the IVC as compared to the SMIC but the difference was not significant (P<0.05). In case of Growth Associated Protein 43 (GAP-43) knockout mice, the number of litters born per dam and the number of pups born per dam were marginally higher in the IVC as compared to those housed in SMIC but the difference was not significant (P<0.05). Only the number of pups weaned per dam were found to be significantly higher as compared to those housed in the SMIC system at P<0.05.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Mice, Transgenic
/
Allergens
/
Hazardous Substances
/
Mice, Knockout
/
GAP-43 Protein
/
Housing
المحددات:
Animals
اللغة:
En
مجلة:
Laboratory Animal Research
السنة:
2017
نوع:
Article