Physiological understanding of host-microbial pathogen interactions in the gut
Korean Journal of Veterinary Research
; : 57-66, 2016.
Article
ي En
| WPRIM
| ID: wpr-20945
المكتبة المسؤولة:
WPRO
ABSTRACT
The gut epithelial barrier, which is composed of the mucosal layer and the intestinal epithelium, has multiple defense mechanisms and interconnected regulatory mechanisms against enteric microbial pathogens. However, many bacterial pathogens have highly evolved infectious stratagems that manipulate mucin production, epithelial cell-cell junctions, cell death, and cell turnover to promote their replication and pathogenicity in the gut epithelial barrier. In this review, we focus on current knowledge about how bacterial pathogens regulate mucin levels to circumvent the epithelial mucus barrier and target cell-cell junctions to invade deeper tissues and increase their colonization. We also describe how bacterial pathogens manipulate various modes of epithelial cell death to facilitate bacterial dissemination and virulence effects. Finally, we discuss recent investigating how bacterial pathogens regulate epithelial cell turnover and intestinal stem cell populations to modulate intestinal epithelium homeostasis.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Stem Cells
/
Virulence
/
Colon
/
Tight Junctions
/
Defense Mechanisms
/
Epithelial Cells
/
Homeostasis
/
Intercellular Junctions
/
Intestinal Mucosa
/
Mucins
اللغة:
En
مجلة:
Korean Journal of Veterinary Research
السنة:
2016
نوع:
Article