New perspectives of biomarkers for the management of chronic hepatitis B
Clinical and Molecular Hepatology
; : 423-431, 2016.
Article
ي En
| WPRIM
| ID: wpr-215525
المكتبة المسؤولة:
WPRO
ABSTRACT
With recent advances in molecular and genomic investigations, the impact of hepatitis B viral and host factors on the progression of chronic HBV infection has been explored. For viral factors, hepatitis B viral load is a strong predictor for liver disease progression. Hepatitis B viral kinetics appear to be important for successful anti-viral therapy. Serum HBsAg level serves as a complementary marker to viral load for the prediction of HBV-related adverse outcomes in patients with low viral load. In those with low viral load, high serum HBsAg level is associated with higher risks of cirrhosis and HCC. Hepatitis B core-related antigen (HBcrAg) induces host immune responses, and the reduction of the HBcrAg level as well as the increment of total anti-HBc level are significantly associated with favorable outcomes. HBV genotypes (genotype C/D) and mutants (basal core promoter and deletion mutation in pre-S genes) are well known viral genetic markers to predict disease progression. For host factors, serum inflammatory biomarkers have been developed to evaluate the HBV-associated hepatic necroinflammation and fibrosis. Host single nucleotide polymorphism on sodium taurocholate cotransporting polypeptide (NTCP, an HBV entry receptor) may be associated with a decreased risk for cirrhosis and HCC. In conclusion, patients with chronic hepatitis B should be evaluated with relevant viral and host markers to identify those who are at a higher risk of liver disease progression and then receive timely antiviral therapy.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
DNA, Viral
/
Biomarkers
/
Hepatitis B virus
/
Risk Factors
/
Hepatitis B, Chronic
/
Polymorphism, Single Nucleotide
/
Organic Anion Transporters, Sodium-Dependent
/
Symporters
/
Hepatitis B e Antigens
/
Hepatitis B Surface Antigens
نوع الدراسة:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
المحددات:
Humans
اللغة:
En
مجلة:
Clinical and Molecular Hepatology
السنة:
2016
نوع:
Article