Effect of Ritonavir-boosting on Atazanavir Discontinuation due to Jaundice in HIV-infected Koreans / 감염과화학요법
Infection and Chemotherapy
; : 175-179, 2012.
Article
ي Ko
| WPRIM
| ID: wpr-216369
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND:
Data regarding differences of intolerance between a ritonavir-unboosted and a ritonavir-boosted atazanavir regimen in HIV-infected Koreans is limited. MATERIALS ANDMETHODS:
A review was conducted of the incidence of severe hyperbilirubinemia (serum total bilirubin >3.1 mg/dL) and discontinuation of atazanavir in HIV-infected patients who had received an atazanavir-containing regimen at Seoul National University Hospital from 2005 to 2009. Patients with active liver disease were excluded from the study.RESULTS:
Of a total of 335 patients receiving an atazanavir-containing regimen, 145 (43.3%) received treatment with a ritonavir-boosted regimen. The cumulative incidence of severe hyperbilirubinemia at three months was 40.5% in patients receiving a ritonavir-boosted atazanavir regimen and 21.4% in patients receiving an un-boosted atazanavir regimen (P<0.001). The cumulative incidence of severe hyperbilirubinemia at 12 months was 58.5% in patients receiving a ritonavir-boosted regimen and 41.3% in those receiving an un-boosted regimen (P=0.008). The proportion of drug discontinuation due to jaundice during the 12-month period was 11.7% in patients receiving a ritonavir-boosted regimen and 5.3% in those receiving an un-boosted regimen (P=0.035).CONCLUSIONS:
Occurrence of severe hyperbilirubinemia and discontinuation of atazanavir due to jaundice was significantly more common in HIV-infected Koreans who received a ritonavir-boosted atazanavir regimen than in those who received a ritonavir-un-boosted atazanavir regimen.Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Oligopeptides
/
Pyridines
/
Bilirubin
/
Incidence
/
HIV
/
Ritonavir
/
Atazanavir Sulfate
/
Hyperbilirubinemia
/
Jaundice
/
Liver Diseases
نوع الدراسة:
Incidence_studies
/
Prognostic_studies
المحددات:
Humans
اللغة:
Ko
مجلة:
Infection and Chemotherapy
السنة:
2012
نوع:
Article