Expression of p27Kip1 Protein in Colorectal Adenocarcinoma
Korean Journal of Pathology
; : 132-137, 2000.
Article
ي Ko
| WPRIM
| ID: wpr-223896
المكتبة المسؤولة:
WPRO
ABSTRACT
p27Kip1 has been recognized as a negative regulator of cell cycle. Reduced level of p27 expression is associated with development and aggressiveness of several human tumors. To investigate the role of p27Kip1 on progression of colorectal adenocarcinoma, we studied 40 cases of human colorectal adenocarcinomas for expression of p27Kip1 protein using an immunohistochemical method, and compared these results with known prognostic parameters of colorectal adenocarcinoma. Among 40 cases of colorectal adenocarcinomas, p27Kip1 expression was detected in the nuclei of tumor cells in 14 cases (35%). The expression rate of p27Kip1 protein was significantly lower in the cases with lymph node metastasis (25.8%) than in those without lymph node metastasis (66.6%) (p<0.05). But it did not correlate with other parameters such as tumor size, histologic grade, vascular invasion, and Ki-67 labeling index. The results suggest that reduced expression of p27Kip1 protein plays a role in biologically aggressive behavior of colorectal adenocarcinoma.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Prognosis
/
Adenocarcinoma
/
Cell Cycle
/
Cyclin-Dependent Kinase Inhibitor p27
/
Lymph Nodes
/
Neoplasm Metastasis
نوع الدراسة:
Prognostic_studies
المحددات:
Humans
اللغة:
Ko
مجلة:
Korean Journal of Pathology
السنة:
2000
نوع:
Article