beta-Amyloid Imaging Probes / 핵의학분자영상
Nuclear Medicine and Molecular Imaging
; : 112-117, 2007.
Article
ي Ko
| WPRIM
| ID: wpr-225215
المكتبة المسؤولة:
WPRO
ABSTRACT
Imaging distribution of beta-amyloid plaques in Alzheimer's disease is very important for early and accurate diagnosis. Early trial of the beta-amyloid plaques includes using radiolabeled peptides which can be only applied for peripheral beta-amyloid plaques due to limited penetration through the blood brain barrier (BBB). Congo red or Chrysamine G derivatives were labeled with Tc-99m for imaging beta-amyloid plaques of Alzheimer patient's brain without success due to problem with BBB penetration. Thioflavin T derivatives gave breakthrough for beta-amyloid imaging in vivo, and a benzothiazole derivative [C-11]6-OH-BTA-1 brought a great success. Many other benzothiazole, benzoxazole, benzofuran, imidazopyridine, and styrylbenzene derivatives have been labeled with F-18 and I-123 to improve the imaging quality. However, [C-11]6-OH-BTA-1 still remains as the best. However, short half-life of C-11 is a limitation of wide distribution of this agent. So, it is still required to develop an Tc-99m, F-18 or I-123 labeled agent for beta-amyloid imaging agent.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Peptides
/
Brain
/
Blood-Brain Barrier
/
Congo Red
/
Diagnosis
/
Alzheimer Disease
/
Half-Life
نوع الدراسة:
Diagnostic_studies
اللغة:
Ko
مجلة:
Nuclear Medicine and Molecular Imaging
السنة:
2007
نوع:
Article