Expression of cytokeratin 10, 16 and 17 as biomarkers differentiating odontogenic keratocysts from dentigerous cysts
Journal of the Korean Association of Oral and Maxillofacial Surgeons
; : 78-84, 2012.
Article
ي En
| WPRIM
| ID: wpr-229233
المكتبة المسؤولة:
WPRO
ABSTRACT
OBJECTIVES: Odontogenic keratocysts (OKCs) have a tendency to recur and possess an aggressive nature. the aim of the present study was to evaluate cytokeratin (CK) expression patterns as a method for the differentiation between dentigerous cysts (DCs) and OKCs, as their histomorphologic appearance are often indistinguishable. MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded tissue sections of 43 OKCs and 38 DCs were immunohistochemically analyzed with i-solution in a quantitative manner in order to evaluate the immunoreactivity of CK 10, 16 and 17. RESULTS: CK 10 expression was evident in 79.1% of OKCs but found in only 18.4% of DCs (P<0.05), and CK 10 expression was observed to occur more frequently in OKCs (mean 25.45%) than in DCs (2.19%) (P<0.05). The expression of CK 16 was evident in 79.1% of OKCs but found in only 7.9% of the DCs (P<0.05) and CK 16 expression was observed to occur more frequently in OKCs (mean 4.33%) than in the DCs (0.61%) (P<0.05). The expression of CK 17 was evident in 88.4% of OKCs but seen in only 15.7% of the DCs (P<0.05) and CK 17 expression was observed to occur more frequently in OKCs (mean 31.11%) than in the DCs (2.37%) (P<0.05). CONCLUSION: The immunohistochemical detection of CK 10, 16 and 17 can be utilized as a valuable biomarker for use in distinguishing between OKCs and DCs, which have clinically significant differential diagnoses.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Thiazines
/
Biomarkers
/
Dentigerous Cyst
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Odontogenic Cysts
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Diagnosis, Differential
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Imines
/
Keratins
نوع الدراسة:
Diagnostic_studies
اللغة:
En
مجلة:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
السنة:
2012
نوع:
Article