Effects of Xixin decoction on enzymes related to O-GlcNAc glycosylation of tau proteins in the brain of rats with sporadic Alzheimer's disease / 南方医科大学学报
Journal of Southern Medical University
; (12): 1442-1447, 2013.
Article
ي Zh
| WPRIM
| ID: wpr-232778
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of Xixin decoction (XXD) on O-GlcNAc transferase (OGT) and O-GlcNAc glycosidase in O-GlcNAc glycosylation of tau proteins in the brain of rats with sporadic Alzheimer's disease (SAD) and explore the possible mechanism.</p><p><b>METHODS</b>Male SD rats were randomly divided into sham-operated group, model group, donepezil group, and low-, moderate-, and high-dose XXD groups. After treatment and behavioral test, the rats were sacrificed for detecting the expressions of OGT and O-GlcNAc glycosidase in the brain using immunohistochemistry and Western blotting.</p><p><b>RESULTS</b>XXD significantly enhanced the expressions of OGT in the hippocampus of SAD rats and lowered the expression of O-GlcNAc glycosidase (P<0.05 or 0.01). OGT and O-GlcNAc glycosidase expressions showed no significant differences between the model group and donepezil group (P>0.05).</p><p><b>CONCLUSION</b>XXD can regulate the expression of OGT and O-GlcNAc glycosidase to enhance O-GlcNAc glycosylation of tau proteins in the hippocampus of SAD rats.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pharmacology
/
Acetylglucosaminidase
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Glycosylation
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Drugs, Chinese Herbal
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Random Allocation
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Tau Proteins
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Rats, Sprague-Dawley
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N-Acetylglucosaminyltransferases
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Streptozocin
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Dose-Response Relationship, Drug
المحددات:
Animals
اللغة:
Zh
مجلة:
Journal of Southern Medical University
السنة:
2013
نوع:
Article