Expressions of OCT4 and CD133 and their correlation in colonic cancer / 南方医科大学学报
Journal of Southern Medical University
; (12): 1434-1436, 2011.
Article
ي Zh
| WPRIM
| ID: wpr-235107
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of Oct4 and CD133 and their correlation in colonic cancer.</p><p><b>METHODS</b>The expression of Oct4 and CD133 were detected by immunohistochemistry in 30 colon cancer specimens and the paired adjacent tissues.</p><p><b>RESULTS</b>The positivity rates of Oct4 and CD133 expression were 83.3% (25/30) and 73.3% (22/30) in colonic cancer tissue, respectively, and their expressions were positively correlated (r=0.586, P<0.05). The matched adjacent tissues showed significantly lower levels of Oct4 and CD133 expressions (P<0.01).</p><p><b>CONCLUSION</b>The expressions of Oct4 and CD133 are upregulated in colonic cancer compared with those in the adjacent tissues and show a positive correlation. Oct4 and CD133 may play an important role in the development of colon cancer.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Peptides
/
General Surgery
/
Glycoproteins
/
Immunochemistry
/
Adenocarcinoma
/
Antigens, CD
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Up-Regulation
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Colonic Neoplasms
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Octamer Transcription Factor-3
/
AC133 Antigen
المحددات:
Adult
/
Aged
/
Female
/
Humans
/
Male
اللغة:
Zh
مجلة:
Journal of Southern Medical University
السنة:
2011
نوع:
Article