Attenuation of cardiac ischemia/reperfusion injury by transient low hydroperoxide pretreatment in rat / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 247-250, 2013.
Article
ي Zh
| WPRIM
| ID: wpr-235388
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate how transient low dose of hydroperoxide pretreatment prevents cardiac ischemia/reperfusion injury.</p><p><b>METHODS</b>SD rats were divided into 4 groups sham operation (Sham), standard ischemia/reperfusion (I/R), ischemic preconditioning (IPC) and IR preceded by low H2O2 treatment. Cardiac function and injury parameter were compared among groups.</p><p><b>RESULTS</b>IPC protected reperfusion injury and improved cardiac function. Low H2O2 treatment played a role in cardioprotection similar to IPC. Low H2O2 was indeed generated in the early phase of simulated ischemia and attenuated cytochrome c release induced by high Ca2+ in isolated mitochondria.</p><p><b>CONCLUSION</b>Low H2O2 plays a critical role in cardioprotection probably by inhibiting mitochondrial permeability transition.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Reperfusion Injury
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Rats, Sprague-Dawley
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Ischemic Preconditioning
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Hydrogen Peroxide
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Methods
المحددات:
Animals
اللغة:
Zh
مجلة:
Chinese Journal of Applied Physiology
السنة:
2013
نوع:
Article