The Effect of Nefopam on Postoperative Fentanyl Consumption: A Randomized, Double-blind Study
The Korean Journal of Pain
; : 110-118, 2016.
Article
ي En
| WPRIM
| ID: wpr-23576
المكتبة المسؤولة:
WPRO
ABSTRACT
BACKGROUND: Nefopam is a non-opioid, non-steroidal, centrally acting analgesic drug. The concomitant use of opioids and nefopam is believed to have many advantages over the administration of opioids alone for postoperative pain management. We conducted a randomized, double-blind study to determine the fentanyl-sparing effect of co-administration of nefopam with fentanyl for postoperative pain management via patient controlled analgesia (PCA). METHODS: Ninety female patients who underwent laparoscopic total hysterectomy under general anesthesia were randomized into 3 groups, Group A, fentanyl 1,000 µg; Group B, fentanyl 500 µg + nefopam 200 mg; and Group C, fentanyl 500 µg + nefopam 400 mg, in a total volume of 100 ml PCA to be administered over the first 48 h postoperatively without basal infusion. The primary outcome was total fentanyl consumption during 48 h; secondary outcomes included pain scores and incidence of side effects. RESULTS: Eighty-one patients were included in the analysis. The overall fentanyl-sparing effects of PCA with concomitant administration of nefopam during the first 48 h postoperatively were 54.5% in Group B and 48.9% group C. Fentanyl use was not significantly different between Groups B and C despite the difference in the nefopam dose. There were no differences among the three groups in terms of PCA-related side effects, although the overall sedation score of Group B was significantly lower than that of Group A. CONCLUSIONS: The concomitant administration of nefopam with fentanyl for postoperative pain management may allow reduction of fentanyl dose, thereby reducing the risk of opioid-related adverse effects.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pain, Postoperative
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Pain Measurement
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Passive Cutaneous Anaphylaxis
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Fentanyl
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Double-Blind Method
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Incidence
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Analgesia, Patient-Controlled
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Deep Sedation
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Analgesics, Opioid
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Hysterectomy
نوع الدراسة:
Clinical_trials
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Incidence_studies
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Prognostic_studies
المحددات:
Female
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Humans
اللغة:
En
مجلة:
The Korean Journal of Pain
السنة:
2016
نوع:
Article