Changes in plasma levels of thrombomodulin and D-dimer in children with different types of Mycoplasma pneumoniae pneumonia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 619-622, 2013.
Article
ي Zh
| WPRIM
| ID: wpr-241459
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the changes in plasma levels of thrombomodulin (TM) and D-dimer (DD) in children with different types of Mycoplasma pneumoniae pneumonia (MPP), and their role in the pathogenesis of MPP in children.</p><p><b>METHODS</b>Fifty-two children with MMP were divided into lobar pneumonia (n=30) and interstitial pneumonia groups (n=22) and another 30 healthy children were selected as the control group. Plasma levels of TM and D-D were measured using enzyme-linked immunosorbent assay and latex-enhanced immunoturbidimetric assay, respectively.</p><p><b>RESULTS</b>The lobar pneumonia, interstitial pneumonia and control groups had median plasma TM levels of 23.83, 15.56 and 8.78 μg/L respectively, with significant differences between the three groups (P<0.01). The lobar pneumonia and interstitial pneumonia groups had significantly higher plasma TM levels than the control group (P<0.01), and the lobar pneumonia group had a significantly higher plasma TM level than the interstitial pneumonia group (P<0.05). Median plasma D-D levels in the lobar pneumonia and interstitial pneumonia groups were significantly higher than the reference value (P<0.01). The lobar pneumonia group had a significantly higher plasma D-D level than the interstitial pneumonia group (0.35 μg/mL vs 0.13 μg/mL; P<0.01), and the percentage of patients with elevated plasma D-D levels was significantly higher in the lobar pneumonia group than in the interstitial pneumonia group (87% vs 59%; P<0.05).</p><p><b>CONCLUSIONS</b>Children with MPP, especially those with lobar pneumonia, have increased plasma levels of TM and D-D. This suggests that damage to vascular endothelial cells and blood hypercoagulability may be involved in the pathogenesis of MPP.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pneumonia, Mycoplasma
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Blood
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Fibrin Fibrinogen Degradation Products
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Thrombomodulin
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Protein Multimerization
المحددات:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
اللغة:
Zh
مجلة:
Chinese Journal of Contemporary Pediatrics
السنة:
2013
نوع:
Article