Natural killer-like T-cell lymphoma/leukemia--a case report and literature review / 中华血液学杂志
Chinese Journal of Hematology
; (12): 226-230, 2006.
Article
ي Zh
| WPRIM
| ID: wpr-243969
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To identify the clinical and pathological features of natural killer-like T-cell lymphoma/leukemia.</p><p><b>METHODS</b>The characteristics of natural killer-like T-cell lymphoma/leukemia was discussed with report a new case and review of literatures.</p><p><b>RESULTS</b>A 16-year-old girl was referred to our hospital because of fever and disseminated cutaneous herpes and ulcer. Atypical lymphoid cells surrounded the dermal vessels with a CD3(+), CD8(+), CD4(-), CD5(-), CD10(-), CD19(-), CD57(-), CD56(+), perforin(+), granzyme B(+) immunophenotype and rearranged T-cell receptor-gamma gene implicated natural killer-like T cell origin. She was treated with prednisone and for several months. Then the patient developed progressive spleen enlargement with overt leukemia, which led to her eventual death.</p><p><b>CONCLUSIONS</b>Natural killer-like T-cell lymphoma/leukemia is a rare disease with distinctive clinical, histopathologic, and immuno phenotypic characteristics. Current treatment modalities are ineffective for most of the patients.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pathology
/
Killer Cells, Natural
/
Leukemia, T-Cell
/
Lymphoma, T-Cell
/
CD56 Antigen
/
Allergy and Immunology
نوع الدراسة:
Prognostic_studies
المحددات:
Adolescent
/
Female
/
Humans
اللغة:
Zh
مجلة:
Chinese Journal of Hematology
السنة:
2006
نوع:
Article