Abnormal expression of cCD79a/cCD22 in acute myeloid leukemia with t (8;21) / 中华血液学杂志
Chinese Journal of Hematology
; (12): 187-189, 2006.
Article
ي Zh
| WPRIM
| ID: wpr-243972
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To report abnormal expression of cCD79a/cCD22 in four cases of acute myeloid leukemia (AML) with t (8;21).</p><p><b>METHODS</b>The characteristics of morphology, immunophenotype, chromosome karyotype (MIC) and clinical manifestations of 4 AML patients with t (8;21) expressing cCD79a/cCD22 were analyzed.</p><p><b>RESULTS</b>The features of the 4 patients were: (1) no difference in gender; (2) young age; (3) exmedullary infiltration may be present; (4) normal number of white blood cells in peripheral blood; (5) morphology showed acute myeloid leukemia with high percentage of blast cells; (6) B-lymphoid and myeloid immunophenotype, and high expression of CD34; (7) frequent depletion of Y chromosome and complex changes of chromosomes; (8) positive for AML1/ETO fusion gene; (9) response well to chemotherapy regimen which simultaneously treated myeloid and lymphocytic leukemia.</p><p><b>CONCLUSION</b>Abnormal expression of cCD79a/cCD22 in AML with t (8;21) (q22;q22) suggested that this kind of leukemia might be related with abnormal expression gene of B cell.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Translocation, Genetic
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Chromosomes, Human, Pair 8
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Chromosomes, Human, Pair 21
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Leukemia, Myeloid, Acute
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Immunophenotyping
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CD79 Antigens
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Sialic Acid Binding Ig-like Lectin 2
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Genetics
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Metabolism
المحددات:
Adolescent
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Adult
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Female
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Humans
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Male
اللغة:
Zh
مجلة:
Chinese Journal of Hematology
السنة:
2006
نوع:
Article