Association of aldosterone synthase gene -344 T/C polymorphism with early renal damage in Han nationality with essential hypertension / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 153-156, 2007.
Article
ي Zh
| WPRIM
| ID: wpr-247364
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether the -344T/C polymorphism of aldosterone synthase gene is associated with early renal damage in Han nationality with essential hypertension in Shandong province.</p><p><b>METHODS</b>Plasma aldosterone concentration and urinary albumin excretion were measured with radioimmunoassays in 225 patients with essential hypertension, and hypertensives were classified as hypertension with normal albuminuria or hypertension with microalbuminuria according to urinary albumin excretion during 24 hours. -344T/C polymorphism of aldosterone synthase gene was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in controls and hypertensives.</p><p><b>RESULTS</b>No significant differences were found in genotype distribution among groups of control, primary hypertension with normal albuminuria and hypertension with microalbuminuria. The C allele frequency in hypertension with microal buminuria group was significantly higher than that in control and hypertension with normal albuminuria group (P < 0.05). In hypertensive patients, plasma aldosterone concentration and urinary albumin excretion of TC+CC genotypes were significantly higher than that of TT genotype ( P< 0.05).</p><p><b>CONCLUSION</b>These results suggest that -344T/C polymorphism of aldosterone synthase gene may be associated with early renal damage in Han nationality with essential hypertension, C allele may be a genetic factor susceptible to renal damage in hypertensives.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Blood
/
Polymorphism, Restriction Fragment Length
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Radioimmunoassay
/
China
/
Polymerase Chain Reaction
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Cytochrome P-450 CYP11B2
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Polymorphism, Single Nucleotide
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Asian People
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Albumins
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Albuminuria
المحددات:
Adult
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Female
/
Humans
/
Male
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
Zh
مجلة:
Chinese Journal of Medical Genetics
السنة:
2007
نوع:
Article