Combination of rabbit antithymocyte globulin and cyclosporine A as first-line therapy for adult severe aplastic anemia / 中华血液学杂志
Chinese Journal of Hematology
; (12): 38-42, 2011.
Article
ي Zh
| WPRIM
| ID: wpr-252017
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the efficacy and side-effects of combination of rabbit antithymocyte globulin (ATG) and cyclosporine A (CsA) as the first-line immunosuppressive therapy (IST) for adult severe aplastic anemia (SAA) patients.</p><p><b>METHODS</b>Adult SAA or very severe aplastic anemia (VSAA) patients treated with rabbit ATG + CsA as first line therapy in our hospital from 2003 to 2008 were retrospectively analysed and the therapeutic response relevant factors were analysed.</p><p><b>RESULTS</b>Seventy-nine patients were enrolled. Of all these patients, 6 died within 3 months after IST. The overall response rate was 82.2% and the median time to transfusion independent was 60 days. The therapeutic response rate in 32 SAA patients (100%) was significantly higher than that in 41 VSAA cases (68.3%) (P = 0.001). Patients with neutrophil response to G-CSF treatment had a higher IST response rate than those without response to G-CSF (100% vs 67.5%, P = 0.001). Sixty-one patients (77.2%) occurred serum sickness reaction. Three patients relapsed and two developed clonal hematological abnormalities after IST. The 3-year overall survival for all the patients was 88.9%.</p><p><b>CONCLUSIONS</b>Rabbit ATG in combination with CsA as first-line IST for adult SAA can lead to excellent treatment outcomes with minor adverse effects.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Retrospective Studies
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Treatment Outcome
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Cyclosporine
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Therapeutic Uses
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Drug Therapy
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Drug Therapy, Combination
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Immunosuppressive Agents
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Anemia, Aplastic
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Antilymphocyte Serum
نوع الدراسة:
Observational_studies
المحددات:
Animals
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Female
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Humans
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Male
اللغة:
Zh
مجلة:
Chinese Journal of Hematology
السنة:
2011
نوع:
Article