Studies on chemical constituents and antibacterial activity from n-butanol extract of Sarcandra glabra / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1843-1846, 2008.
Article
ي Zh
| WPRIM
| ID: wpr-252212
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the chemical constituents and the antibacterial activity from n-butanol extract of Sarcandra glabra.</p><p><b>METHOD</b>The compounds were isolated by Diaion HP-20, Sephadex LH-20, MCI CHP-20 and silica gel column chromatographic methods. Their structures were identified on the basis of physicochemical and spectroscopic analysis. The antibacterial effect of the compounds were measured against Staphylococcus aureus by filterpaper slice method, finally the antibacterial ring in each group was recorded after 24 hours.</p><p><b>RESULT</b>Seven constituents were isolated and elucidated as 5, 7, 3', 4'-tetrahydroxy-6-C-beta-D-glucopyranosylflavanone (1), kaempferol-3-O-beta-D-glucuronide (2), fraxidin (3), isofraxidin (4), isofraxidin-7-O-beta-D-glucopyranoside (5), kaempferol (6), pinostrobin (7). Diameters (in mm) of antibacterial ring in the compounds 2, 5, 6 were orderly recorded as follows 14.67 +/- 0.08, 11.14 +/- 1.06, 8.26 +/- 1.26 and the compound 4 is not effective.</p><p><b>CONCLUSION</b>Compounds 1-3 and 5 were isolated from S. glabra for the first time.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pharmacology
/
Staphylococcus aureus
/
Drugs, Chinese Herbal
/
Magnetic Resonance Spectroscopy
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Chemistry
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Magnoliopsida
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Butanols
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Anti-Bacterial Agents
اللغة:
Zh
مجلة:
China Journal of Chinese Materia Medica
السنة:
2008
نوع:
Article