Comparison of Immune Response by Virus Infection and Vaccination to 2009 Pandemic Influenza A/H1N1 in Children
Journal of Korean Medical Science
; : 274-279, 2013.
Article
ي En
| WPRIM
| ID: wpr-25347
المكتبة المسؤولة:
WPRO
ABSTRACT
We aimed to compare the immune response induced by natural infection with 2009 pandemic influenza A/H1N1 (pH1N1) virus and by monovalent pH1N1 vaccination in children and adolescents. This cross-sectional clinical study was conducted at 3 hospitals in Korea from February to May 2010. A total of 266 healthy subjects aged from 6 months to 18 yr were tested for the presence of the antibody against pH1N1 using hemagglutination inhibition (HI) test. Information about pH1N1 vaccination and laboratory-confirmed pH1N1 infection history was obtained. The overall rate of HI titers of > or = 1:40 against pH1N1 was 38.7%, and the geometric mean titer (GMT) was 20.5. Immunogenicity of pH1N1 vaccination only was reflected by a 41.1% of seroprotection rate and a GMT of 22.5. Immunogenicity of natural infection only was reflected by a 61.0% of seroprotection rate and a GMT of 40.0. GMT was significantly higher in the subjects of natural infection group than in the subjects of pH1N1 vaccination group (P < 0.001). The immune responses induced by natural pH1N1 infection exceed those induced by pH1N1 vaccinations.
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Hemagglutination Inhibition Tests
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Cross-Sectional Studies
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Vaccination
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Influenza, Human
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Influenza A Virus, H1N1 Subtype
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Antibodies, Neutralizing
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Pandemics
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Antibody Formation
نوع الدراسة:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
المحددات:
Adolescent
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Child
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Child, preschool
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Humans
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Infant
اللغة:
En
مجلة:
Journal of Korean Medical Science
السنة:
2013
نوع:
Article