Distribution of HCV genotypes in Chinese Han population with chronic hepatitis C / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 417-422, 2015.
Article
ي Zh
| WPRIM
| ID: wpr-255175
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the distribution of HCV genotypes in Chinese Han population with chronic hepatitis C (CHC).</p><p><b>METHODS</b>This randomized multicenter study included 1 014 CHC patients from 28 hospitals in different regions of China. SPSS 20.0 was applied to analyze the relationship among region, HCV genotype, gender and the replication level of HCV-RNA.</p><p><b>RESULTS</b>HCV 1 genotype (56.80%) was the most common genotype. The majority of CHC patients were of genotype 1, 2, 3, 6 in the order of frequency, except those in southwestern, southern and central China. HCV 1, 2, 3, 6 genotypes were most common among male patients in southern China; among female patients in northern China; among male patients in northern and northwestern China and among male patients in northwestern China, respectively (all P <0.05). There was no statistical significance between different genders in other regions. The high viral load was more common than the low viral load among HCV 1, 2, 3, 6 genotype-infected patients.</p><p><b>CONCLUSION</b>There are different distributions of HCV genotypes among the different regions. In addition, HCV genotypes are correlated with gender and HCV-RNA load.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Virology
/
Randomized Controlled Trials as Topic
/
China
/
Hepacivirus
/
Viral Load
/
Hepatitis C, Chronic
/
Asian People
/
Genetics
/
Genotype
نوع الدراسة:
Clinical_trials
المحددات:
Female
/
Humans
/
Male
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
Zh
مجلة:
Journal of Zhejiang University. Medical sciences
السنة:
2015
نوع:
Article