Evaluation of preoperative radiotherapy or chemoradiotherapy in sphincter preservation for locally advanced middle-low rectal cancer / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 225-227, 2007.
Article
ي Zh
| WPRIM
| ID: wpr-255679
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of preoperative radiotherapy or chemoradiotherapy on the sphincter preservation and local tumor control as well as survival for the patient with locally advanced middle-low rectal cancer.</p><p><b>METHODS</b>121 locally advanced middle-low rectal cancer patients were treated with preoperative radiotherapy or chemoradiotherapy followed by surgery after rest of 4 to 6 weeks. 103 of these patients who underwent radical surgery were finally included in this study. The irradiation regimen was 40 Gy/4 - 5 weeks, whereas 57 of these 103 patients received concurrent chemotherapy of 5-Fu or Xeloda. Sphincter-preserving surgery was performed in 59 patients and abdominoperineal resection in 44 patients. The survival was estimated by Kaplan-Meier model, and the differences between groups were compared using Log rank test. Multivariate analysis was performed by Cox's model.</p><p><b>RESULTS</b>Ten patients (9.7%) achieved a complete pathological response (pCR) to preoperative radiotherapy or chemoradiotherapy. The sphincter preservation rate was 57.3%. The 3-year overall survival (OS) and disease free survival (DFS) was 66.3% and 59.5%, respectively. Univariate analysis showed that pCR and postoperative pTNM stage were prognostic factors affecting survival, whereas, only pTNM stage was an independent prognostic factor (P = 0.003) by multivariate analysis.</p><p><b>CONCLUSION</b>Neoadjuvant preoperative radiotherapy and chemoradiotherapy is effective in local tumor control and improving survival for locally advanced middle-low rectal cancer, which can raise the rate of sphincter-preserving surgery, and achieve comparable result to abdominoperineal resection.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Particle Accelerators
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Pathology
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Rectal Neoplasms
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Therapeutics
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Preoperative Care
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Adenocarcinoma
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Antineoplastic Combined Chemotherapy Protocols
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Leucovorin
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Multivariate Analysis
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Retrospective Studies
نوع الدراسة:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
المحددات:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
اللغة:
Zh
مجلة:
Chinese Journal of Oncology
السنة:
2007
نوع:
Article