Lipopolysaccharide affects male reproductive function through Toll-like receptors / 中华男科学杂志
National Journal of Andrology
; (12): 163-168, 2013.
Article
ي Zh
| WPRIM
| ID: wpr-256942
المكتبة المسؤولة:
WPRO
ABSTRACT
Reproductive tract infection is one of the factors of male infertility, but the mechanisms responsible are hitherto poorly defined. Recent studies show that one of the microbial pattern-recognition receptors, Toll-like receptor (TLR) signaling pathway, plays a critical role in inflammation-induced male infertility. Lipopolysaccharide (LPS), a major component in the cell wall of gram-negative bacteria, could induce inflammatory response through TLRs. A large number of researches suggest that TLRs express widely in the male reproductive tract and LPS-induced inflammatory reaction through TLRs may affect male fertility. This article presents an overview on how LPS-induced inflammation through TLRs affects male fertility in terms of its influence on the testis, epididymis and sperm quality.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pathology
/
Lipopolysaccharides
/
Toll-Like Receptors
/
Genital Diseases, Male
/
Gram-Negative Bacteria
/
Infertility, Male
/
Inflammation
/
Metabolism
المحددات:
Humans
/
Male
اللغة:
Zh
مجلة:
National Journal of Andrology
السنة:
2013
نوع:
Article