Role of serum neutrophil elastase determination in the diagnosis of acute exacerbation of asthma in preschool children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 396-399, 2016.
Article
ي Zh
| WPRIM
| ID: wpr-261221
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the role of serum neutrophil elastase (NE) level in acute exacerbation of asthma in preschool children.</p><p><b>METHODS</b>A total of 85 preschool children who were diagnosed with asthma between January 2008 and January 2010 were classified into acute exacerbation group (n=44) and non-acute exacerbation group (n=41). Thirty-five children who received physical examination served as the control group. The enzyme-linked immunosorbent assay was used to determine the serum levels of NE and interleukin-8 (IL-8). The receiver operating characteristic (ROC) curve was used for NE evaluation.</p><p><b>RESULTS</b>Both the acute and non-acute exacerbation groups had higher serum levels of NE and IL-8 than the control group, and the acute exacerbation group had significantly higher serum levels of NE and IL-8 than the non-acute exacerbation group (P<0.05). The serum level of NE was positively correlated with that of IL-8 (r=0.48, P<0.05). With serum NE level >27.73 μg/L as the cut-off value for diagnosing acute exacerbation of asthma, the sensitivity was 65.9%, the specificity was 95.1%, and the area under the ROC curve was 0.87 (P<0.01).</p><p><b>CONCLUSIONS</b>The determination of serum NE level in preschool children with asthma helps to diagnose the acute exacerbation of asthma.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Asthma
/
Blood
/
ROC Curve
/
Interleukin-8
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Leukocyte Elastase
/
Diagnosis
نوع الدراسة:
Diagnostic_studies
/
Prognostic_studies
المحددات:
Child
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Child, preschool
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Female
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Humans
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Male
اللغة:
Zh
مجلة:
Chinese Journal of Contemporary Pediatrics
السنة:
2016
نوع:
Article