Mechanism of the effect of Tongluo Recipe against glomerular sclerosis in rats / 南方医科大学学报
Journal of Southern Medical University
; (12): 1198-1201, 2008.
Article
ي Zh
| WPRIM
| ID: wpr-270176
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of Tongluo Recipe on the expression of collagen IV (Col IV), fibronectin (FN), laminin (LN), transforming growth factor-beta1 (TGF-beta1) in rat renal tissues and explore the mechanism underlying these effects in rats with glomerular sclerosis.</p><p><b>METHODS</b>The pathological changes in the renal tissues of rats with glomerular sclerosis were observed microscopically, and the expressions of Col IV, FN, LN, and TGF-beta1 were detected using immunohistochemical staining and image analysis system.</p><p><b>RESULTS</b>Tongluo Recipe significantly decreased the expressions of Col IV, FN, LN and TGF-beta1 in the renal tissue of rats with glomerular sclerosis (P<0.05 or P<0.01) and obviously alleviated the renal pathologies (P<0.01).</p><p><b>CONCLUSION</b>The therapeutic effects of Tongluo Recipe are probably mediated by lowered expressions of Col IV, FN, LN and TGF-beta1.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pathology
/
Drugs, Chinese Herbal
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Glomerulosclerosis, Focal Segmental
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Random Allocation
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Fibronectins
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Treatment Outcome
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Rats, Sprague-Dawley
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Collagen Type IV
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Therapeutic Uses
/
Drug Therapy
المحددات:
Animals
اللغة:
Zh
مجلة:
Journal of Southern Medical University
السنة:
2008
نوع:
Article