Effect of ginsenoside Rg1 on the influence of neprilysin expression induced by LPS in BT325 cell line / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 890-893, 2004.
Article
ي Zh
| WPRIM
| ID: wpr-272774
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of ginsenoside Rg1 on the influence of neprilysin expression induced by LPS in BT325 cell line.</p><p><b>METHOD</b>MTT was used to measure the levels of the survival rate of BT325 cultured with ginsenoside Rg1 and LPS in different concentrations. The expression of NEP was measured by RT-PCR.</p><p><b>RESULT</b>The survival rate of BT325 was obviously inhibited by LPS, and the expression of NEP was decreased. The survival rate of BT325 was obviously raised by ginsenoside Rg1, and the expression of NEP was increased.</p><p><b>CONCLUSION</b>LPS can cause cell damage, and decrease the expression of NEP. Ginsenoside Rg1 can exert neuroprotective properties which protects BT325 cell line from the cell toxicity of LPS.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pathology
/
Pharmacology
/
Plants, Medicinal
/
Drugs, Chinese Herbal
/
Neprilysin
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Cell Survival
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Chemistry
/
Lipopolysaccharides
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Neuroprotective Agents
/
Ginsenosides
المحددات:
Humans
اللغة:
Zh
مجلة:
China Journal of Chinese Materia Medica
السنة:
2004
نوع:
Article