Your browser doesn't support javascript.
loading
Synthesis and biological evaluation of noscapine analogues as microtubule-interfering agents / 药学学报
Yao Xue Xue Bao ; (12): 1347-1357, 2012.
Article ي En | WPRIM | ID: wpr-274655
المكتبة المسؤولة: WPRO
ABSTRACT
A series of noscapine analogues have been synthesized via 13-step reaction starting from 2-hydroxy-3-methoxybenzaldehyde. Anti-tumor activities of these compounds were evaluated against HL-60 cell lines in vitro by the standard MTT assay. It was found that most of these derivatives showed appreciable inhibitory activity against HL-60 and tubulin polymerization. The results also indicated that the potency of compound 31 is about three times more than that ofnoscapine against HL-60 cell line and tubulin polymerization. Moreover, it induced a massive accumulation of cells in G2/M phase. These results showed noscapine and its derivatives were worth to be intensively studied further.
الموضوعات
النص الكامل: 1 الفهرس: WPRIM الموضوع الرئيسي: Pharmacology / Tubulin / Cell Cycle / HL-60 Cells / Tubulin Modulators / Polymerization / Metabolism / Antineoplastic Agents / Noscapine المحددات: Humans اللغة: En مجلة: Yao Xue Xue Bao السنة: 2012 نوع: Article
النص الكامل: 1 الفهرس: WPRIM الموضوع الرئيسي: Pharmacology / Tubulin / Cell Cycle / HL-60 Cells / Tubulin Modulators / Polymerization / Metabolism / Antineoplastic Agents / Noscapine المحددات: Humans اللغة: En مجلة: Yao Xue Xue Bao السنة: 2012 نوع: Article