The design, synthesis and anticancer activity of 4-heteroarylamino-3-cyanoquinolines as dual inhibitors of c-Src and iNOS / 药学学报
Acta Pharmaceutica Sinica
; (12): 288-295, 2009.
Article
ي Zh
| WPRIM
| ID: wpr-278268
المكتبة المسؤولة:
WPRO
ABSTRACT
Because c-Src and iNOS are key regulatory enzymes in tumorigenesis, a new series of 4-heterocycle amine-3-quinolinecarbonitriles as potent dual inhibitors of both enzymes were designed, synthesized and evaluated as multiple targets agents in cancer therapy. All compounds were evaluated by two related enzyme inhibition assays and an anti-proliferation assay in vitro. The results showed that most compounds inhibited c-Src and iNOS well. The best compound 33 inhibited both enzymes with the IC50 values of 0.0484 micromol x L(-1) and 34.5 micromol x (-1), respectively. Some of the compounds also showed moderate anti-proliferation activities at 10 micromol x L(-1) against colon cancer HT-29 and liver cancer HepG2 cell lines.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pharmacology
/
Quinolines
/
Protein-Tyrosine Kinases
/
Drug Design
/
Chemistry
/
Drug Delivery Systems
/
Src-Family Kinases
/
Cell Line, Tumor
/
Cell Proliferation
/
Nitric Oxide Synthase Type II
المحددات:
Humans
اللغة:
Zh
مجلة:
Acta Pharmaceutica Sinica
السنة:
2009
نوع:
Article