Camouflage of HLA-I antigen in lymphocyte surface / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 622-624, 2003.
Article
ي Zh
| WPRIM
| ID: wpr-278826
المكتبة المسؤولة:
WPRO
ABSTRACT
The objective of this study was to investigate the method and effect of blocking the specific reaction between lymphocyte HLA-I antigen and its antibody. The lymphocytes were disposed with 12 mmol/L methoxypolyethelene glycol benzotriazol carbonate (mPEG-BTC) in concentration gradient in PBS (pH 7.4) at 22 degrees C. The effect of the modified lymphocytes was detected by microlymphocytotoxicity assay. The results showed that lymphocytes modified by mPEG-BTC did not react with related HLA-I antibodies in microcytotoxicity test. It is suggested that the specific reaction between HLA-I antigen of lymphocyte and HLA-I antibodies can be completely camouflaged by mPEG-BTC in PBS (pH 7.4) under 22 degrees C room temperature.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pharmacology
/
Polyethylene Glycols
/
Triazoles
/
Lymphocytes
/
Histocompatibility Antigens Class I
/
Cytotoxicity, Immunologic
/
Allergy and Immunology
/
Antigen-Antibody Reactions
المحددات:
Humans
اللغة:
Zh
مجلة:
Journal of Experimental Hematology
السنة:
2003
نوع:
Article