Study on mRNA expression of immune-related genes in patients with allergic dermatitis induced by trichloroethylene / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 816-819, 2011.
Article
ي Zh
| WPRIM
| ID: wpr-282502
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study mRNA expression of immune-related genes (Foxp3, GATA3, CTLA4 and T-bet) in peripheral blood of the patients with allergic dermatitis induced by trichloroethylene (TCE).</p><p><b>METHODS</b>The peripheral blood samples were collected from 8 healthy workers (control group) and 8 patients with allergic dermatitis induced by TCE (case group). Real-time quantitative PCR was applied to detect mRNA expression of immune-related genes (Foxp3, GATA3, CTLA4, T-bet).</p><p><b>RESULTS</b>The mRNA expression levels of Foxp3, GATA3 and CTLA4 genes increased by 115%, 97% and 241% in case group, as compared with control group (P < 0.01). The mRNA expression level of T-bet gene decreased by 47% in case group, as compared with control group (P < 0.01).</p><p><b>CONCLUSION</b>The mRNA expression levels of some immune-related genes changed in patients with allergic dermatitis induced by TCE, those genes may play an important role in TCE-induced allergy.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Trichloroethylene
/
RNA, Messenger
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Case-Control Studies
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Gene Expression
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Dermatitis, Occupational
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T-Box Domain Proteins
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Allergy and Immunology
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GATA3 Transcription Factor
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Forkhead Transcription Factors
/
CTLA-4 Antigen
نوع الدراسة:
Observational_studies
/
Risk_factors_studies
المحددات:
Adult
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Female
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Humans
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Male
اللغة:
Zh
مجلة:
Chinese Journal of Industrial Hygiene and Occupational Diseases
السنة:
2011
نوع:
Article