Comparative study on in vitro drug-release between Tuizhang ophthalmic gel and Tuizhang oculentum / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 683-687, 2007.
Article
ي Zh
| WPRIM
| ID: wpr-283408
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To prepare tuizhang gel to cure cataract, the characteristics of Tuizhang gel on the drug-releasing in vitro were evaluated by compared with Tuizhang oculentum.</p><p><b>METHOD</b>The emodin and chrysophanol in the releasing mediator were determined by HPLC, and the drug releasing characteristics of Tuizhang gel and Tuizhang oculentum were studied by bag filter method.</p><p><b>RESULT</b>The emodin and chrysophanol in Tuizhang gel released (98.3, 1.1)%, (95.8, 1.8)% within 24 hours, respectively, while those in tuizhang oculentum released (10.62, 0.7)%, (10.46, 0.4)%, respectively. The emodin and chrysophanol in Tuizhang gel released more quickly and completely than in Tuizhang oculentum, so Tuizhang gel has enhanced the bioavailability.</p><p><b>CONCLUSION</b>The Tuizhang gel is characterized by slow-release to some degree, and it shows a promising future on ophthalmic drug delivery.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Ointments
/
Pharmacology
/
Plants, Medicinal
/
Solubility
/
Acrylic Resins
/
Drugs, Chinese Herbal
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Pharmacokinetics
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Chemistry
/
Anthraquinones
/
Emodin
اللغة:
Zh
مجلة:
China Journal of Chinese Materia Medica
السنة:
2007
نوع:
Article