Comparative study on in vitro drug-release between Tuizhang ophthalmic gel and Tuizhang oculentum / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To prepare tuizhang gel to cure cataract, the characteristics of Tuizhang gel on the drug-releasing in vitro were evaluated by compared with Tuizhang oculentum.</p><p><b>METHOD</b>The emodin and chrysophanol in the releasing mediator were determined by HPLC, and the drug releasing characteristics of Tuizhang gel and Tuizhang oculentum were studied by bag filter method.</p><p><b>RESULT</b>The emodin and chrysophanol in Tuizhang gel released (98.3, 1.1)%, (95.8, 1.8)% within 24 hours, respectively, while those in tuizhang oculentum released (10.62, 0.7)%, (10.46, 0.4)%, respectively. The emodin and chrysophanol in Tuizhang gel released more quickly and completely than in Tuizhang oculentum, so Tuizhang gel has enhanced the bioavailability.</p><p><b>CONCLUSION</b>The Tuizhang gel is characterized by slow-release to some degree, and it shows a promising future on ophthalmic drug delivery.</p>