Effect of Rhizoma coptidis and Radix rehmanniae with different ratio on pharmacokinetics of berberine in rats / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1795-1797, 2007.
Article
ي Zh
| WPRIM
| ID: wpr-287890
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Rhizoma Coptidis and Radix Rehmanniae with the different ratio on the pharmacokinetics of berberine in rats.</p><p><b>METHOD</b>24 rats were grouped to 4 groups randomly. Decoction, in which the proportion of Rhizoma Coptidis to Radix Rehmanniae is 1:0, 1:1, 1:4, 1:8 differently, was intragastrically given to the 4 groups. HPLC was used to determine concentration of berberine in serum. We adopted DAS 2.0 to analysis pharmacokinetic parameters of berberine.</p><p><b>RESULT</b>The concentration-time curves was all fitted to two-compartment model with a weight of 1/C2. Difference of 4groups in C(max), AUC(0-t), AUC(0-infinity), is significant (P <0.05).</p><p><b>CONCLUSION</b>Radix Rehmanniae of large dose can effectively enhance berberine's bioavailability in rats.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Plants, Medicinal
/
Berberine
/
Blood
/
Drugs, Chinese Herbal
/
Pharmacokinetics
/
Biological Availability
/
Random Allocation
/
Chemistry
/
Rats, Sprague-Dawley
/
Plant Roots
نوع الدراسة:
Prognostic_studies
المحددات:
Animals
اللغة:
Zh
مجلة:
China Journal of Chinese Materia Medica
السنة:
2007
نوع:
Article