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Effect of Rhizoma coptidis and Radix rehmanniae with different ratio on pharmacokinetics of berberine in rats / 中国中药杂志
Article ي Zh | WPRIM | ID: wpr-287890
المكتبة المسؤولة: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Rhizoma Coptidis and Radix Rehmanniae with the different ratio on the pharmacokinetics of berberine in rats.</p><p><b>METHOD</b>24 rats were grouped to 4 groups randomly. Decoction, in which the proportion of Rhizoma Coptidis to Radix Rehmanniae is 1:0, 1:1, 1:4, 1:8 differently, was intragastrically given to the 4 groups. HPLC was used to determine concentration of berberine in serum. We adopted DAS 2.0 to analysis pharmacokinetic parameters of berberine.</p><p><b>RESULT</b>The concentration-time curves was all fitted to two-compartment model with a weight of 1/C2. Difference of 4groups in C(max), AUC(0-t), AUC(0-infinity), is significant (P <0.05).</p><p><b>CONCLUSION</b>Radix Rehmanniae of large dose can effectively enhance berberine's bioavailability in rats.</p>
الموضوعات
النص الكامل: 1 الفهرس: WPRIM الموضوع الرئيسي: Plants, Medicinal / Berberine / Blood / Drugs, Chinese Herbal / Pharmacokinetics / Biological Availability / Random Allocation / Chemistry / Rats, Sprague-Dawley / Plant Roots نوع الدراسة: Prognostic_studies المحددات: Animals اللغة: Zh مجلة: China Journal of Chinese Materia Medica السنة: 2007 نوع: Article
النص الكامل: 1 الفهرس: WPRIM الموضوع الرئيسي: Plants, Medicinal / Berberine / Blood / Drugs, Chinese Herbal / Pharmacokinetics / Biological Availability / Random Allocation / Chemistry / Rats, Sprague-Dawley / Plant Roots نوع الدراسة: Prognostic_studies المحددات: Animals اللغة: Zh مجلة: China Journal of Chinese Materia Medica السنة: 2007 نوع: Article