Correlation between Ultrasound-guided Diffuse Optical Tomography and Hypoxia-inducible Factor-1Α of Breast Cancer / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 341-345, 2016.
Article
ي En
| WPRIM
| ID: wpr-289858
المكتبة المسؤولة:
WPRO
ABSTRACT
Objective To investigate the correlation between ultrasound-guided diffuse optical tomography (US-DOT) and hypoxia-inducible factor-1Α (HIF-1Α) of breast cancer. Methods Totally 69 patients with pathologically confirmed breast cancer underwent preoperative conventional breast ultrasonography examinations and US-DOT at Peking Union Medical College Hospital From October 2007 to February 2010 were enrolled in this study.After surgery,immunohistochemical staining of HIF-1Α and CD34 were performed,and the differences of total hemoglobin concentration (THC) and microvessel density (MVD) between HIF-1Α positive and negative groups were analyzed. Results HIF-1Α was positive in 12 cases (17.4%) and negative in 57 cases (82.6%). The average THC and MVD of HIF-1Α-positive cases were (274.763±77.661) Μmol/L and (33.8±10.8)/0.2 mm(2) respectively. The average THC and MVD of HIF-1Α-negative cases were (228.059±65.760)Μmol/L and (28.4±7.4)/0.2 mm(2). MVD(t=2.049,P=0.04) and THC(t=2.167,P=0.034) of HIF-1Α-positive group were significantly higher than those of HIF-1Α-negative group. Conclusions HIF-1Α can promote tumor angiogenesis and thus increase the blood supply and THC. As an indicator of tumor blood supply,THC can indirectly reflect the angiogenic activity of breast cancer.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Breast Neoplasms
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Diagnostic Imaging
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Ultrasonography, Mammary
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Tomography, Optical
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Hypoxia-Inducible Factor 1, alpha Subunit
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Metabolism
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Neovascularization, Pathologic
نوع الدراسة:
Diagnostic_studies
المحددات:
Female
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Humans
اللغة:
En
مجلة:
Acta Academiae Medicinae Sinicae
السنة:
2016
نوع:
Article