Is EQ-5D a valid quality of life instrument in patients with Parkinson's disease? A study in Singapore
Annals of the Academy of Medicine, Singapore
; : 521-528, 2009.
Article
ي En
| WPRIM
| ID: wpr-290362
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>INTRODUCTION</b>The purpose of the present study was to evaluate the validity of the EQ-5D in patients with Parkinson's disease (PD) in Singapore.</p><p><b>MATERIALS AND METHODS</b>In a cross-sectional survey, patients with PD completed English or Chinese version of the EQ-5D, the 8-item Parkinson's disease questionnaire (PDQ-8), and questions assessing socio-demographic and health characteristics. Clinical data were retrieved from patients' medical records. The validity of the EQ-5D was assessed by testing a-priori hypotheses relating the EQ-5D to the PDQ-8 and clinical data.</p><p><b>RESULTS</b>Two hundred and eight PD patients (English speaking: 135) participated in the study. Spearman correlation coefficients between the EQ-5D and PDQ-8 ranged from 0.25 to 0.75 for English-speaking patients and from 0.16 to 0.67 for Chinese-speaking patients. By and large, the EQ-5D scores were weakly or moderately correlated with Hoehn and Yahr stage (correlation coefficients: 0.05 to 0.43), Schwab and England Activities of Daily Living score (correlation coefficients: 0.10 to 0.60), and duration of PD (correlation coefficients: 0.16 to 0.43). The EQ-5D index scores for patients with dyskinesia or "wearing off" periods were significantly lower than those without these problems. The EQ-5D Visual Analog Scale (EQ-VAS) scores also differed for English-speaking patients with deferring dyskinesia, "wearing off" periods, or health transition status; however, such differences were not observed in patients who completed the survey in Chinese.</p><p><b>CONCLUSIONS</b>The EQ-5D questionnaire appears valid for measuring quality of life in patients with PD in Singapore. However, the validity of EQ-VAS in Chinese-speaking patients with PD should be further assessed.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Parkinson Disease
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Quality of Life
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Reference Standards
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Singapore
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Cross-Sectional Studies
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Surveys and Questionnaires
نوع الدراسة:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
المحددات:
Aged
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Female
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Humans
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Male
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
Annals of the Academy of Medicine, Singapore
السنة:
2009
نوع:
Article