Association between single nucleotide polymorphisms on chromosome 17q and the risk of prostate cancer in a Chinese population / 癌症
Chinese Journal of Cancer
; (12): 721-730, 2011.
Article
ي En
| WPRIM
| ID: wpr-294472
المكتبة المسؤولة:
WPRO
ABSTRACT
In European populations, 7 single nucleotide polymorphisms (SNPs) on chromosome 17q, 3 SNPs on 17q12, and 4 SNPs on 17q24.3 were recently identified to be closely related to the risk of prostate cancer by a genome-wide association study. In Japanese populations, the correlation between 2 SNPs on 17q and the risk of prostate cancer and tumor aggressiveness was also confirmed by a large-scale experiment. However, whether 17q is associated with prostate cancer and its clinical manifestations in Chinese populations is still unknown. Therefore, we conducted a case-control study in a northern Chinese population and tested 2 SNPs, rs4430796 and rs1859962, on 17q in 124 prostate cancer patients and 111 controls using polymerase chain reaction-high resolution melting curve (PCR-HRM) combined with sequencing. We analyzed the association of the 2 SNPs with the risk of prostate cancer as well as patients' lifestyles, onset ages, Gleason scores, PSA levels, and pathologic stages. We found a significant difference in the G allele of SNP rs1859962 (P = 0.035, OR = 1.51, 95% CI = 1.03-2.21) but not in the rs4430796 genotype frequency or allele frequency distribution between prostate cancer patients and the controls (P > 0.05). Neither of the SNPs was significantly associated with the onset age, Gleason score, PSA level, pathologic stage, or other clinical indicators of patients with prostate cancer (P > 0.05). Our results show that polymorphism of the G allele of SNP rs1859962 is associated with the risk of prostate cancer in a Chinese population.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Prostatic Neoplasms
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Chromosomes, Human, Pair 17
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Case-Control Studies
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Risk Factors
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Polymorphism, Single Nucleotide
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Asian People
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Neoplasm Grading
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Gene Frequency
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Genetics
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Genotype
نوع الدراسة:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
المحددات:
Aged
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Aged80
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Humans
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Male
اللغة:
En
مجلة:
Chinese Journal of Cancer
السنة:
2011
نوع:
Article