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Analysis of prognostic factors influencing the outcome of intrahepatic cholangiocarcinoma / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 845-848, 2009.
Article ي Zh | WPRIM | ID: wpr-295222
المكتبة المسؤولة: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the clinicopathologic factors influencing the outcome of surgically treated intrahepatic cholangiocarcinoma (ICC) and to explore the proper treatment choice of ICC.</p><p><b>METHODS</b>The clinicopathological data of 43 surgically treated ICC patients in our hospital were retrospectively analyzed. Of the 43 patients, hepatic resection was performed in 40 patients, ethanol injection in 2, and laparoscopic exploration alone in 1. Kaplan-Meier method and Cox regression model were used for the analysis of factors influencing survival after operation.</p><p><b>RESULTS</b>The accumulative 1-, 3- and 5-year survival rates were 64.4%, 30.9%, 25.8% for the whole group, and 74.7%, 33.3%, 27.8% for the 40 patients with hepatic resection, respectively. Univariate analysis revealed that tumor size, carcinoembryonic antigen (CEA) level, lymph node involvement and TNM stage were factors significantly affecting the survival (P < 0.05). Cox multivariate analysis demonstrated that only tumor size and lymph node involvement were the independent factors significantly affecting the survival (P < 0.05).</p><p><b>CONCLUSION</b>Our results show that tumor size and lymph node involvement are independent factors affecting the survival. CEA level and TNM stage are important prognostic factors for surgical management. Radical resection is still the optimal treatment for patient with intrahepatic cholangiocarcinoma.</p>
الموضوعات
النص الكامل: 1 الفهرس: WPRIM الموضوع الرئيسي: Pathology / General Surgery / Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Blood / Carcinoembryonic Antigen / Proportional Hazards Models / Survival Rate / Retrospective Studies / Follow-Up Studies نوع الدراسة: Observational_studies / Prognostic_studies المحددات: Adult / Aged / Female / Humans / Male اللغة: Zh مجلة: Chinese Journal of Oncology السنة: 2009 نوع: Article
النص الكامل: 1 الفهرس: WPRIM الموضوع الرئيسي: Pathology / General Surgery / Bile Duct Neoplasms / Bile Ducts, Intrahepatic / Blood / Carcinoembryonic Antigen / Proportional Hazards Models / Survival Rate / Retrospective Studies / Follow-Up Studies نوع الدراسة: Observational_studies / Prognostic_studies المحددات: Adult / Aged / Female / Humans / Male اللغة: Zh مجلة: Chinese Journal of Oncology السنة: 2009 نوع: Article