A new indole alkaloid from the stems of Brucea mollis / 药学学报
Acta Pharmaceutica Sinica
; (12): 225-229, 2014.
Article
ي Zh
| WPRIM
| ID: wpr-297989
المكتبة المسؤولة:
WPRO
ABSTRACT
Eight compounds were isolated from the stems of Brucea mollis by various chromatographic techniques such as column chromatography on silica gel and Sephadex LH-20, and preparative HPLC, and their structures were elucidated as bruceolline O (1), 1-(1-beta-glucopyranosyl)-1H-indole-3-carbaldehyde (2), canthin-6-one (3), 11-hydroxycanthin-6-one (4), 9-methoxycanthin-6-one (5), 4-methoxycanthin-6-one (6), infractin (7), and beta-carboline-1-propionic acid (8). The cytotoxic activities of compounds 1-8 against HCT-8 and A549 human cell lines were determined, but none of them exhibited significant activity (IC 50 > 10 micromol x L(-1)). Among them, compound 1 is a new indole alkaloid, and compounds 2 and 5-7 were isolated from this plant for the first time.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pharmacology
/
Plants, Medicinal
/
Carbolines
/
Molecular Structure
/
Chemistry
/
Plant Stems
/
Indole Alkaloids
/
Brucea
/
Cell Line, Tumor
/
Antineoplastic Agents, Phytogenic
المحددات:
Humans
اللغة:
Zh
مجلة:
Acta Pharmaceutica Sinica
السنة:
2014
نوع:
Article