Effect of hypoxia on the expression of urokinase-type plasminogen activator in human tongue squamous cell carcinoma cells (Tca8113) / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 211-213, 2005.
Article
ي Zh
| WPRIM
| ID: wpr-300334
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the expression of urokinase-type plasminogen activator (uPA) in human tongue squamous carcinoma cells (Tca8113) under hypoxia, in order to explore the relation between hypoxia and invasion and metastasis of oral cancer.</p><p><b>METHODS</b>Under different hypoxic times(0, 3, 6, 12, 24 h), the expression of uPA protein was examined quantitatively using immunohistochemical technique (IH) and flow cytometry (FCM).</p><p><b>RESULTS</b>Hypoxia promoted the expression of uPA. The longer hypoxic time was, the higher expression of uPA was.</p><p><b>CONCLUSION</b>Hypoxia can promote invasion and metastasis of oral squamous carcinoma through stimulating the expression of uPA.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Mouth Neoplasms
/
Tongue Neoplasms
/
Carcinoma, Squamous Cell
/
Urokinase-Type Plasminogen Activator
/
Neoplasm Invasiveness
المحددات:
Humans
اللغة:
Zh
مجلة:
West China Journal of Stomatology
السنة:
2005
نوع:
Article