Progress of nanometer vector polyethylenimine applied in gene therapy / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 195-198, 2011.
Article
ي Zh
| WPRIM
| ID: wpr-306594
المكتبة المسؤولة:
WPRO
ABSTRACT
Polyethylenimine (PEI) is a kind of nanometer nonviral vector frequently applied in gene transfection. It is simple and easy to prepare and to modify and relatively safe compared to viral vectors. In recent years, PEI has been utilized in many research areas for gene delivery to stem cells in vitro or targeted gene delivery to cells in the brain. This review reveals that the cytotoxicity and low transfection efficiency of PEI requires to be improved. However brain-targeted modification indicates the promising prospect of PEI for gene therapy in cerebrovascular diseases.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Polyethyleneimine
/
Transfection
/
Genetic Therapy
/
Chemistry
/
Stem Cell Transplantation
/
Nanostructures
/
Genetic Vectors
/
Methods
المحددات:
Humans
اللغة:
Zh
مجلة:
Journal of Biomedical Engineering
السنة:
2011
نوع:
Article