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Effect of concanavalin A on expression of MAPEG mRNA in Balb/c mouse brain / 浙江大学学报·医学版
Article ي Zh | WPRIM | ID: wpr-310358
المكتبة المسؤولة: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the gene expression of MAPEG in the cortex of concanavalin A (Con A)-induced mouse immune inflammatory model and the effect of cyclosporine A (Cs A).</p><p><b>METHODS</b>Male Balb/c mouse immune inflammation model was developed by intravenous injection of Con A (20 mg/kg). Cs A (150 mg/kg) was intravenously infected prior to Con A administration. The MAPEG expressions were determined by RT-PCR.</p><p><b>RESULT</b>mGST1, mGST3, LTC(4)S, FLAP and mPGES-1 were detected by RT-PCR but not mGST2. Eight hours after Con A treatment, mGST1 level was up-regulated to 1.2 approximately 1.5 folds of control with or without Cs A treatment. mGST3ìLTC(4)S, FLAP and mPGES-1 mRNA levels were not influenced by Con A administration.</p><p><b>CONCLUSION</b>Immune mechanism may be not involved in mGST1 up-regulation in this model and Con A does not alter arachidonic acid metabolism in cortex.</p>
الموضوعات
النص الكامل: 1 الفهرس: WPRIM الموضوع الرئيسي: Pharmacology / Brain / Carrier Proteins / Eicosanoids / Cyclosporine / Concanavalin A / Intramolecular Oxidoreductases / Toxicity / 5-Lipoxygenase-Activating Proteins / Prostaglandin-E Synthases المحددات: Animals اللغة: Zh مجلة: Zhejiang Daxue xuebao. Yixue ban السنة: 2009 نوع: Article
النص الكامل: 1 الفهرس: WPRIM الموضوع الرئيسي: Pharmacology / Brain / Carrier Proteins / Eicosanoids / Cyclosporine / Concanavalin A / Intramolecular Oxidoreductases / Toxicity / 5-Lipoxygenase-Activating Proteins / Prostaglandin-E Synthases المحددات: Animals اللغة: Zh مجلة: Zhejiang Daxue xuebao. Yixue ban السنة: 2009 نوع: Article