Elimination Rate of Serum Lactate is Correlated with Amyotrophic Lateral Sclerosis Progression / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 28-32, 2016.
Article
ي En
| WPRIM
| ID: wpr-310716
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>Mitochondrial dysfunction plays an important role in the pathogenesis of amyotrophic lateral sclerosis (ALS). We aimed to demonstrate mitochondrial dysfunction in ALS using a lactate stress test and to examine the relationship between mitochondrial dysfunction with motor deterioration.</p><p><b>METHODS</b>We enrolled 116 patients and observed clinical variables, including the survival state.</p><p><b>RESULTS</b>Patients with a rapid slope of revised ALS functional rating scales (ALSFRS-r) (>20 U/year) exhibited the slowest elimination rate (median -4.67 × 10-3 mmol·L-1·min-1 , coefficient of variation, 590.15%), the shortest duration (0.63 ± 0.28 years) and the worst ALSFRS-r (32.59 ± 4.93). Patients with a moderate slope of ALSFRS-r (10-20 U/year) showed a moderate elimination rate (median -11.33 × 10-3 mmol·L-1·min-1 , coefficient of variation, 309.89%), duration (1.16 ± 0.45 years), and ALSFRS-r (34.83 ± 6.11). The slower progressing (<10 U/year group) patients exhibited a rapid elimination rate (median -12.00 × 10-3 mmol·L-1·min-1 , coefficient of variation 143.08%), longer duration (median 3 years, coefficient of variation 193.33%), and adequate ALSFRS-r values (39.58 ± 9.44). Advanced-phase ALS patients also showed slower elimination rate (ER, quartiles -17.33, -5.67, 4.00) and worse ALSFRS-r (34.88 ± 9.27), while early-phase patients showed a more rapid ER (quartiles -25.17, -11.33, -3.50) and better ALSFRS-r (39.28 ± 7.59). These differences were statistically significant. Multiple linear regression analysis revealed strong direct associations among ER, ALSFRS-r slope (standard beta = 0.33, P = 0.007), and forced vital capacity (predict %) (standard beta = -0.458, P = 0.006, adjusted for ALSFRS-r, course and onset region). However, the data obtained from 3 years of follow-up showed no statistically significant difference in the survival rates between the most rapid and slowest ER groups.</p><p><b>CONCLUSION</b>There is a potential linear relationship between ER and motor deterioration in ALS. Slower ER might be associated with faster disease progression.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pathology
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Blood
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Retrospective Studies
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Analysis of Variance
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Mortality
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Disease Progression
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Lactic Acid
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Kaplan-Meier Estimate
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Amyotrophic Lateral Sclerosis
نوع الدراسة:
Observational_studies
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Prognostic_studies
المحددات:
Adult
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Female
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Humans
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Male
اللغة:
En
مجلة:
Chinese Medical Journal
السنة:
2016
نوع:
Article