Effects of gypsum on the firing of pyrogen-treated thermosensitive neurons in PO/AH of cats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 320-323, 2008.
Article
ي Zh
| WPRIM
| ID: wpr-310735
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the possible central mechanism of antipyretic effects of Chinese medicine gypsum.</p><p><b>METHODS</b>Gypsum was injected after the fever model was established. The firing rate of thermosensitive neurons in preoptic-anterior hypothalamus(PO/AH) region was recorded by using extracellular microelectrode technique.</p><p><b>RESULTS</b>The injection of pyrogen evoked decrease in firing rate of the warm-sensitive neurons and increase in the cold-sensitive neurons in the region of PO/AH; the changes of the firing rate of pyrogen- treated warm-sensitive and cold-sensitive neurons could be reversed by the injection of gypsum.</p><p><b>CONCLUSION</b>The result may suggest that antipyretic action of gypsum is mediated by its influences on the thermosensitivity neurons in the region of PO/AH.</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Pharmacology
/
Physiology
/
Preoptic Area
/
Pyrogens
/
Action Potentials
/
Calcium Sulfate
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Hypothalamus, Anterior
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Materia Medica
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Antipyretics
/
Fever
المحددات:
Animals
اللغة:
Zh
مجلة:
Chinese Journal of Applied Physiology
السنة:
2008
نوع:
Article