Bitter Melon Powder Protects against Obesity-associated Fatty Liver Disease by Improving Colonic Microenvironment in Rats with High-fat Diet-induced Obesity / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 611-615, 2017.
Article
ي En
| WPRIM
| ID: wpr-311371
المكتبة المسؤولة:
WPRO
ABSTRACT
This study explored how bitter melon powder (BMP) alters the colonic microenvironment during the development of obesity-associated fatty liver in rats. We observed that BMP effectively inhibited the body weight gain and lipid accumulation in the liver, ameliorated glucose intolerance, and increased the colon weight after an 8-week treatment compared to that in the high-fat diet (HFD) group. BMP significantly decreased fecal water toxicity towards HT-29 cells, as revealed by the cell counting kit (CCK)-8 assay results, and the mRNA expression of Toll-like receptor 4 (TLR4) in colon mucosa. Additionally, gut permeability in the BMP group was restored to normal levels. Finally, BMP alleviated the inflammatory state of the rat colon mucosa and liver tissues as well as the systemic inflammation.
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Powders
/
Dietary Fats
/
Chemistry
/
Colon
/
HT29 Cells
/
Momordica charantia
/
Fatty Liver
/
Feces
/
Obesity
المحددات:
Animals
/
Humans
اللغة:
En
مجلة:
Biomedical and Environmental Sciences
السنة:
2017
نوع:
Article