Serum Thyroglobulin-A Sensitive Biomarker of Iodine Nutrition Status and Affected by Thyroid Abnormalities and Disease in Adult Populations / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 508-516, 2017.
Article
ي En
| WPRIM
| ID: wpr-311385
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the usefulness of the thyroglobulin (Tg) level in adults as a nutritional biomarker of iodine status and to identify the factors related to the serum Tg level.</p><p><b>METHODS</b>A cross-sectional study was conducted in adult populations of areas differing in iodine nutrition from three provinces (Autonomous Region) in China. Serum levels of thyroid hormones and Tg as well as thyroid autoantibodies were measured. The thyroid volume and nodule were measured by ultrasound. A multivariate linear regression analysis was used to assess iodine intake and other indeterminate factors associated with the serum Tg level.</p><p><b>RESULTS</b>A total of 573 adults were recruited for this study. The serum Tg levels differed significantly among the three groups (22.27 μg/L, 9.73 μg/L and 15.77 μg/L in the excess, more-than-adequate, and deficient groups, respectively). The results of multivariate linear regression analysis indicate that excess and deficient iodine intake, goiter, thyroid nodule, hypothyroidism are significantly related with higher Tg level, and TgAb positivity is significantly related with lower serum Tg.</p><p><b>CONCLUSION</b>The serum Tg level reflects abnormal thyroid function and is a sensitive functional biomarker of iodine nutrition status.</p>
Key words
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Thyroglobulin
/
Thyroid Diseases
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Thyroid Gland
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Blood
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Biomarkers
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China
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Cross-Sectional Studies
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Iodine
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Metabolism
نوع الدراسة:
Diagnostic_studies
/
Observational_studies
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Prevalence_studies
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Risk_factors_studies
المحددات:
Adult
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Female
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Humans
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Male
البلد/الأقليم حسب الموضوع:
Asia
اللغة:
En
مجلة:
Biomedical and Environmental Sciences
السنة:
2017
نوع:
Article