Effects of total flavone of Abelmoschl Manihot L. Medic on the function of platelets and its mechanism / 中国结合医学杂志
Chinese journal of integrative medicine
; (12): 57-59, 2005.
Article
ي En
| WPRIM
| ID: wpr-314148
المكتبة المسؤولة:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of total flavone of Abelmoschl Manihot L. Medic (TFA) on the function of platelets and to explore its mechanism.</p><p><b>METHODS</b>Rat models of artery-veins bypassing thrombus formation were used. The platelets of rabbits were collected. Platelet aggregation was induced by collagen and intracellular calcium ion concentration ([Ca(2+)]i) was assayed by Fura-2 method.</p><p><b>RESULTS</b>TFA (25, 50, 100 mg/kg) significantly and dose-dependently reduced the weight of thrombus. TFA (0.025, 0.05, 0.1 mg/ml) possessed dose-dependant inhibitory effects on rabbits' platelet aggregation induced by collagen. TFA significantly reduced the resting and CaCl(2)-induced increase of free intracellular calcium concentration ([Ca(2+)]i) in rabbit platelet in vitro.</p><p><b>CONCLUSION</b>TFA has an antiplatelet effect via the inhibition on the influx of Ca(2+).</p>
النص الكامل:
1
الفهرس:
WPRIM
الموضوع الرئيسي:
Osmolar Concentration
/
Pharmacology
/
Platelet Function Tests
/
Blood
/
Blood Platelets
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Calcium Chloride
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Drugs, Chinese Herbal
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Platelet Aggregation Inhibitors
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Calcium Channel Blockers
/
Carotid Artery Thrombosis
نوع الدراسة:
Prognostic_studies
المحددات:
Animals
اللغة:
En
مجلة:
Chinese journal of integrative medicine
السنة:
2005
نوع:
Article